Innovation New Jersey
  • Home
  • Our Coalition
    • Contact Us
  • News
  • Resources
    • State Supports
    • Federal Supports
    • Higher Ed Supports
  • Join Us

Innovation News

Everything Innovation. Everything New Jersey.
Follow us and stay connected.

Rutgers Research: Cognitive Decline With Low Vitamin D

9/20/2015

0 Comments

 
New Brunswick, NJ - According to Jeff Minerd of MedPage Today, "Longitudinal study examined trajectories in racially mixed cohort  n a racially diverse group of older adults, those with low vitamin D lost episodic memory and executive function faster than those with adequate levels, researchers reported online in JAMA Neurology. In addition, vitamin D levels in older adults with dementia were found to be 20% lower on average than in normal adults, reported a team of investigators led by Joshua Miller, PhD, of Rutgers University in New Brunswick, NJ."
In the U.S., 42% of the general adult population is either deficient or insufficient in vitamin D, according to a recent government health survey, Miller and colleagues noted.

The proportion is even higher among Hispanics (69%) and African Americans (82%), the investigators said.

Previous studies have reported links between vitamin D and cognitive decline, but they were conducted in primarily white cohorts. "Therefore, we investigated the associations between hypovitaminosis D and cognitive decline in an ethnically diverse cohort of older adults," Miller and colleagues wrote.

The 382 study participants were 41% white, 30% African American, 25% Hispanic, and 4% other. Their mean age was 75.5. More than half (62%) were women.

Serum levels of 25-hydroxyvitamin D (25-OHD) were measured at baseline. Study participants were categorized as vitamin D deficient (less than 12 ng/mL), insufficient (12-20 ng/mL), or adequate (20-50 ng/mL), according to Institute of Medicine guidelines.

Neuropsychological tests were administered at baseline and at approximate yearly intervals for an average follow-up of 4.8 years. At baseline, 17.5% of participants had dementia, 32.7% had mild cognitive impairment, and 49.5% were cognitively normal. Key results included the following:

The average baseline vitamin D level for the entire cohort was 19.2 ng/mL, which is just below adequate.

Approximately 61% of the entire cohort was either deficient (26%) or insufficient (35%) in vitamin D.

The mean vitamin D level among whites was on the low side of adequate (21.7 ng/mL). Mean levels were insufficient among African Americans (17.9 ng/mL) and Hispanics (17.2 ng/mL).

Mean vitamin D levels were significantly lower in the dementia group compared to the normal group (16 ng/mL versus 20 ng/mL; P=0.006).

Compared to study participants with adequate vitamin D, those who were deficient experienced significantly faster rates of decline in episodic memory (β= -0.04, [SE=0.02],P=0.049) and executive function (β= -0.05, [SE=0.02], P=.01).

Similarly, vitamin D insufficient individuals also experienced faster rates of decline in episodic memory (β= -0.06, [SE=0.02], P < .001) and executive function (β= -0.04, [SE=0.02], P=0.008).

Vitamin D status was not significantly associated with decline in semantic memory or visuospatial ability.

When analyzing rates of cognitive decline among study participants, the investigators controlled for factors including age, sex, education, ethnicity, vascular risk, and APOE4genotype.

"Our results extend current knowledge regarding the effect of hypovitaminosis D on cognitive function and underscore the relevance of identifying high-risk populations with low [vitamin] D status," Miller and colleagues said. "Our data suggest that hypovitaminosis D may be another risk factor for dementia among individuals of nonwhite race/ethnicity."
0 Comments



Leave a Reply.

    Do not miss a single innovative moment and sign up for our newsletter!
    Weekly updates


    Categories

    All
    3D Printing
    Academia
    Acquisitions
    Aerospace
    Agriculture
    AIDS
    Algae
    Alumni
    Animals
    Architecture
    Astrophysics
    Autism
    Awards
    Big Data
    Bioethics
    Biofuel
    Biomedical
    BioNJ
    Bioterrorism
    Bit Coins
    Brain Health
    Business
    Camden
    Cancer
    CCollege
    Cellular
    Centenary
    Chemistry
    ChooseNJ
    Climate Change
    Clinical Trials
    Cloud Tech
    Collaboration
    Computing
    Congress
    Coriell
    Council On Innovation
    Crowdfunding
    Cybersecurity
    DARPA
    Defense
    Degree
    Dementia
    Dental Health
    DOC
    DOD
    DOE
    Drew
    Drones
    Drug Creation
    Einstein's Alley
    Electricity
    Energy
    Engineering
    Entrepreneurship
    Environmental
    FAA
    Fairleigh Dickinson
    FDA
    Federal Budget
    Federal Government
    Federal Labs
    Federal Program
    Finance
    Food Science
    Fort Monmouth
    Fuel Cells
    Funding
    Genome
    Geography
    Geology
    Global Competition
    Google
    Governor Christie
    Grant
    Hackensack
    HackensackUMC
    Healthcare
    Health Care
    HHS
    HINJ
    Hospitals
    Immigration
    Incubator
    Infrastructure
    International
    Internet
    Investor
    IoT
    IP
    IT
    Jobs
    Johnson & Johnson
    K-12
    Kean
    Kessler
    Legislation
    Logistics
    Manufacturing
    Medical Devices
    Med School
    Mental Health
    Mentor
    Microorganisms
    Molecular Biology
    Montclair
    NAS
    Neuroscience
    Newark
    New Jersey
    NIFA
    NIH
    NIST
    NJBDA
    NJBIA
    NJ Chemistry Council
    NJCU
    NJDOLWD
    NJEDA
    NJEDge
    NJHF
    NJII
    NJIT
    NJMEP
    NJPAC
    NJPRO
    NJTC
    Nonprofit
    NSF
    OpEd
    Open Data
    OSHE
    OSTP
    Parasite
    Patents
    Paterson
    Patients
    Perth Amboy
    Pharma
    POTUS
    PPPL
    Princeton
    Prosthetics
    Ranking
    Rare Disease
    R&D Council
    Report
    Resiliency
    Rider
    Robotics
    Rowan
    Rutgers
    SBA
    Seton Hall
    Siemens
    Smart Car
    Smart Cities
    Software
    Solar
    Space
    SSTI
    Startup
    State Government
    STEM
    Stevens
    Stockton
    Subatomic
    Supports
    Sustainability
    Taxes
    TCNJ
    Teachers
    Telecom
    Therapy
    Thermodynamics
    Transportation
    Undergraduate
    USEDA
    Verizon
    Video Game
    Virtual Reality
    Water
    WHO
    William Paterson
    Women In STEM
    Workforce Development

Home   Coalition   News   Resources   Events   Join Us
Picture
Innovation New Jersey Coalition
10 West Lafayette Street
Trenton, NJ 08608-2002
609-858-9507